Researchers
at the Institute of Photonic Sciences (ICFO) have developed a
lab-on-a-chip device that can detect protein cancer markers in a drop of
blood, working as a very early cancer-detection system. The device can
detect very low concentrations of markers and is reliable, cheap and
portable, making it attractive for deployment in remote areas of the
world.
Early detection is of paramount importance for successful cancer treatment. Unfortunately, many cancers are detected late on, when the illness has already spread to millions of cells, because most medical devices are only able to detect tumors once they have already become macroscopic.
Early detection is of paramount importance for successful cancer treatment. Unfortunately, many cancers are detected late on, when the illness has already spread to millions of cells, because most medical devices are only able to detect tumors once they have already become macroscopic.
Things could now change thanks to the research led by Prof. Romain
Quidant. He and his team developed a small, portable device that uses
fluidic micro-channels to detect even the smallest concentrations of
cancer markers from a single drop of blood.
When blood enters the device, it is distributed to a network of
micro-channels. Each channel contains gold nanoparticles along with a
specific antibody receptor: if a cancer marker protein is present in the
blood, it will stick to the nanoparticles. According to the
researchers, the device is then able to monitor the number of markers in
the blood for each channel, providing an accurate assessment of the
patient's cancer risk.
"The most fascinating finding is that we are capable of detecting
extremely low concentrations of this protein in a matter of minutes,
making this device an ultra-high sensitivity, state-of-the-art, powerful
instrument that will benefit early detection and treatment monitoring
of cancer," says Quidant.
The device was developed by combining the latest advances in
plasmonics, nano-fabrication, microfluids and surface chemistry, and it
holds the promise for earlier cancer diagnoses and a prompt choice of a
suitable treatment.
A paper detailing the advance appears in the journal Nano Letters.
Source: ICFO
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